June 13, 2008

Subject: New safety information regarding CHAMPIX® (varenicline tartrate)

Pfizer Canada in collaboration with Health Canada would like to notify healthcare professionals of important safety information regarding CHAMPIX, and post-marketing reports of serious neuropsychiatric adverse events, including depressed mood, agitation, hostility, changes in behaviour, suicidal ideation and suicide, as well as worsening of pre-existing psychiatric illness (previously diagnosed or not). Since the introduction of CHAMPIX in Canada, in April 2007 through April 30, 2008, a total of 226 Canadian cases of neuropsychiatric adverse events have been reported. For the same time period, there have been 708 534 prescriptions filled for CHAMPIX in Canada

May 16, 2008- Health Canada is warning consumers not to use the natural health product Trophic Kelp & Glutamic Acid HCl due to the health risk posed by exposure to high levels of iodine. Women who are pregnant or breastfeeding, and individuals with thyroid disease such as Graves' disease are particularly at risk.

Mar 11,2008- Chattem Canada Issues Urgent Voluntary Nationwide Recall of Icy Hot® HEAT THERAPYTM Products Chattem Canada is initiating a voluntary Nationwide recall of its Icy Hot HEAT THERAPY products, including consumer "samples" that were included on a limited promotional basis in cartons of Aspercreme® product. Chattem Canada is recalling these products in conjunction with the recall initiated by its parent company in the U.S. (Chattem, Inc.), which has received consumer reports of burns as well as skin irritation resulting from consumer use, or possible misuse, of these HEAT THERAPY products in the U.S. In Canada there have been only four, and less severe, complaints received to date.

Sponsored by